Dervan Cohort

DERVAN Cohort

New Directions for Research in Diabetes in India

The Harbinger of Future Diabetes: An Adolescent and
Preconception Health Perspective

Stage 1

Funded by Rajiv Gandhi Science & Technology Commission (RGSTC), Government of Maharashtra

Stage 2

Sponsored by Rama Purushottam Foundation

Project Start: January 2019


Background & Purpose

Adolescent Health

Adolescence is a critical phase of rapid growth that demands extra energy and nutrients. Inadequate nutrition during this period—especially among girls—can have serious, long-term health consequences. Poor growth and undernutrition in adolescence increase the risk of developing non-communicable diseases (NCDs) like diabetes, hypertension, and cardiovascular disease later in life. These effects may also be passed on to the next generation, influencing the health of their future children.

The DERVAN Cohort is the first detailed, long-term study of its kind in the Konkan region. It aims to investigate the biological, nutritional, and cognitive profiles of adolescent girls, and to follow them—and their offspring—for 20 years. The ultimate goal is to identify early-life risk factors for diabetes and related NCDs, enabling preventive measures to be developed and implemented.


Study Design

1,520
Participants

Adolescent girls

16-18
Age Group

Years

3
Taluks

Ratnagiri district

217
Villages

Covered

Geographical Coverage

Guhagar

55 villages – 500 girls

Sangmeshwar

87 villages – 498 girls

Chiplun

75 villages – 522 girls


Investigations Conducted

Body Composition

  • Anthropometry (height, weight, waist & hip measurements)
  • Bio-impedance analysis

Biochemistry

  • Fasting blood samples to measure glucose, insulin, lipid profile, micronutrients, and
    hormones

Organ Imaging

  • Abdominal ultrasonography (liver, pancreas, kidneys)

Bio-repository

  • Long-term storage of blood, urine, saliva, DNA, and MicroRNA samples for future studies

Cognitive Assessment

  • Tests to measure memory, problem-solving, and other mental skills

Long-term Follow-up

  • 20-year tracking of participants and their children to assess the impact of adolescent
    nutrition on adult and intergenerational health


Significance

This research bridges the gap between adolescent health and the future risk of diabetes in India. By focusing on pre-conception health, the DERVAN Cohort study is redefining preventive strategies for NCDs, starting from the teenage years.


National & International Collaborations

National Partners

  • Tata Institute of Fundamental Research (TIFR)
  • Centre for Chronic Disease Control (CCDC – ICMR Collaborating Centre)
  • Dr. Balasaheb Sawant Konkan Krishi Vidyapeeth, Dapoli

International Partners

  • Bill & Melinda Gates Foundation
  • Toddler Food Partners

These collaborations provide both financial and technical support, enabling
advanced investigations and capacity-building in the region.


Current Status

Baseline Recruitment

Completed

Health Profiling

Ongoing

Bio-repository

Established

Data Analysis

In Progress

Data analysis in progress to identify correlations between adolescent malnutrition and
adult NCD risk.


Key Outcomes Expected

Early Identification

Risk markers for diabetes and other NCDs in adolescent girls

Policy Impact

Evidence-based recommendations for adolescent nutrition programs

Generational Health

Strategies to break the cycle of malnutrition and chronic disease


“From adolescence to adulthood – building a healthier future for Konkan’s girls and generations to come.”


Investigations at the time of enrolment and follow up

Dervan Cohort Project

DERVAN cohort follow up schedule

Dervan Cohort Project

Results (n=1520)

Dervan Cohort Project

Biochemical Parameters (n=1520)

Dervan Cohort Project


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